So I got this mission:
Seems fun, right? It's even better, one of the rewards is the loss of 3 infamy
One of the benefits of good relations with the Pope. The game isn't completely transparent in what you can expect of a mission. From what the message says you'd expect to get an infamy discount on capturing Napeolitan land, but that's not the case. Unfortunately, because I would've liked to get the university in Ancona. I liberated Urbino instead (for the umpteenth time), let's see if I can convince them to be my vassal.
I did get Ferrara's university though. It was conquered by the Ottomans, and with the cheap holy war CB I couldn't resist annexing it.