I don't see a lot of problems with the CoT in mexico surviving once colonisation starts. Afaik a CoT will survive if the value is high enough, even with just one trading nation in it. I've seen a playtrough were some guy owned all of the americas and was the only nation using the CoT's there. All 6 merchant monopolies with a slew of empty spots in the CoT's.
Keeping the 2 incan CoT's alive will be difficult I think. We've both seen one die off in our games even before we arrived. With the western coast being much harder to colonise I think you won't see more than 1 CoT there most of the time.
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I fed my Dog the American Dream
Well, he rolled over and he started to scream
He said, I dig the taste of salt but it don't keep me alive yeah, yeah
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